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[DOI: 10.5281/zenodo.23091236] The gut-liver-heart axis in the Pathogenesis of Atrial Fibrillation and Nonischemic Ventricular Tachycardia
Abstract: Traditional paradigms frame atrial fibrillation and nonischemic reentrant ventricular tachycardia as isolated electrical or structural issues of the myocardium. Yet, clinical data demonstrates a high bidirectional correlation in their prevalence and remodeling characteristics. We propose that their induction and maintenance may be driven by a self-amplifying gut-liver-heart axis, wherein environmental xenobiotics and an unhealthy lifestyle destabilize cardiac tissue to create arrhythmogenic substrate.
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[DOI: 10.5281/zenodo.22832520] The gut-liver axis as initiator of celiac disease
Abstract: Traditional paradigms frame celiac disease onset as a localized enteropathy. We propose a novel "Two-Hit, Spatial-Feedback Model" demonstrating how a self-amplifying, bidirectional loop between the duodenum and liver drives autoimmune destruction.
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